Mandy Meijer

This study evaluates the trade-off between spatial resolution and proteome depth in spatial proteomics using SLACS, showing that few-cell sampling maintains proteomic information while increasing spatial specificity.

The paper performs multi-omics analysis of choroid plexus across development in mice and rats, identifying cellular remodeling, immune gene activation, and a novel epithelial subtype.

The paper profiles histone modifications in adult human CNS cells, revealing epigenetic memory of developmental programs in oligodendroglia.

This study identifies an early wave of oligodendrogenesis in the human forebrain at PCW 8 using single-cell RNA-Seq and ATAC-Seq, supported by spatial gene expression analysis.

This study identifies a primed chromatin state in oligodendroglia that facilitates rapid activation of immune gene programs in multiple sclerosis.

The paper investigates cell-type specific 3D chromatin structures in the brain using immunoGAM, finding TAD melting, neuron-specific contacts, and compartmentalization patterns related to gene expression and neurodegenerative diseases.

This study shows that PADI2-mediated citrullination is essential for oligodendrocyte differentiation, myelination, and motor function, with implications for remyelination therapies.

The paper uses single-cell transcriptomics to show that embryonic Pdgfra+ cells give rise to OPCs with convergent transcriptional profiles in different CNS regions.