Dual E3 ligase recruitment by monovalent degraders enables redundant and tuneable degradation of SMARCA2/4
Valentina A. Spiteri, Dmitri Segal, Alejandro Correa-Sáez, Kentaro Iso, Ryan Casement, Miquel Muñoz i Ordoño, Mark A. Nakasone, Gajanan J. Sathe, Caroline Schätz, Hannah E. Peters, Mark Dorward, Lisa Kainacher, Angus D. Cowan, Alessio Ciulli, Georg E. Winter
This study shows that a monovalent MGD can recruit two E3 ligases redundantly to degrade SMARCA2/4, with tunable ligase preference through chemical and genetic modifications.
bioRxiv · Aug 4, 2025 · PreprintBiochemistry