Leveraging the BAF chromatin remodeling complex for targeted transcriptional rewiring in cancer
Dmitri Segal, Lisa Kainacher, Timo Muffel, Thomas M. Geiger, Severin Lechner, Danai Mavridi, Dimitrios-Ilias Balourdas, Michael Nelles, Caroline Schätz, Stefan Knapp, Andreas C. Joerger, Radosław P. Nowak, Christian Steinebach, Georg E. Winter
This paper introduces TRIPs, neomorphic molecules that recruit BAF complexes to rewire BCL6 in DLBCL, inducing apoptosis through chromatin remodeling.
bioRxiv · Apr 1, 2026 · PreprintCancer Biology