Dmitri Segal

The paper maps over 20,000 human protein-protein interactions mediated by short linear motifs using a peptide library screening approach.

This paper introduces TRIPs, neomorphic molecules that recruit BAF complexes to rewire BCL6 in DLBCL, inducing apoptosis through chromatin remodeling.

This study shows that a monovalent MGD can recruit two E3 ligases redundantly to degrade SMARCA2/4, with tunable ligase preference through chemical and genetic modifications.

The paper introduces a method to identify direct protein substrates of small-molecule degraders using degradome analysis and mass spectrometry.