tRNA modifications are required for stress granule formation and melanoma metastasis
Riley O. Hughes, Hannah J Davis, Leona A. Nease, Paul Zumbo, Mauro Danielli, Wyatt C. Tran, Kilian Maidhof, Kosmas Kosmas, Evgeny Kanshin, Shino Murakami, M. Graciela Cascio, Kellsey P. Church, Kelsey N. Aguirre, Ines Delclaux, Frank John Slack, , Elena Piskounova
This study shows that tRNA modification mcm5s2U34 is essential for stress granule formation and melanoma metastasis, suggesting it as a therapeutic target.
bioRxiv · Aug 20, 2025 · PreprintCancer Biology