Inhibition of VCP preserves retinal structure and function in autosomal dominant retinal degeneration
Blanca Arango‐González, Merve Sen, Rosellina Guarascio, Kalliopi Ziaka, Eva Maria del Amo, Kwan L. Hau, Hannah Poultney, Rowan Asfahani, Arto O. Urtti, Tsui‐Fen Chou, Sylvia Bolz, Raymond J. Deshaies, Wadood Haq, Michael E. Cheetham, Marius Ueffing
This study shows that inhibiting VCP activity rescues degenerating P23H rod cells and improves their function in retinal models of adRP.
bioRxiv · Nov 17, 2020 · PreprintNeuroscience