Preventing light-induced toxicity in a new mouse model of rhodopsin sector retinitis pigmentosa
Rosellina Guarascio, Kalliopi Ziaka, Kwan L. Hau, Davide Piccolo, Sara Eliza Nieuwenhuis, Adriana Bakoulina, Rowan Asfahani, Mònica Aguilà, Dimitra Athanasiou, Diana Sefic Svara, Yumei Li, Rui Chen, Michael E. Cheetham
This study develops a mouse model of rhodopsin sector RP and shows that dim red light and S1PR agonist treatment can prevent light-induced photoreceptor degeneration.
bioRxiv · May 14, 2025 · PreprintNeuroscience