In vivo evidence that SORL1, encoding the endosomal recycling receptor SORLA, can function as a causal gene in Alzheimer's Disease
Olav M. Andersen, Nikolaj Bøgh, Anne Marlene Landau, Gro Grunnet Pløen, Anne Mette G. Jensen, Giulia Monti, Benedicte Parm Ulhøi, Jens Randel Nyengaard, Kirsten Rosenmay Jacobsen, Arne Lund Jørgensen, Ida E. Holm, Marianne Kristensen, Aage Kristian Olsen Alstrup, Esben Søvsø Szocska Hansen, Charlotte Elisabeth Teunissen, , Charlotte Brandt Sørensen
This study shows that SORL1 haploinsufficiency in pigs mimics early AD biomarker changes without neurodegeneration, supporting its role as a causal gene in Alzheimer's disease.
Cell Reports Medicine · Sep 1, 2022Peer-reviewedNeuroscience