BiochemistryNucleic Acids ResearchPeer-reviewed
High-throughput competitive binding assay for targeting RNA with small molecules: discovery of new PreQ1 riboswitch ligands
Sophie E.L. Wintermans, Jana S Hoffmann, Victor van Kuijk…·René C. L. Olsthoorn
This paper develops a competitive binding HTS assay to identify small molecule ligands for bacterial PreQ1 riboswitches, discovering 4 hits with activity against multiple riboswitches and one showing translation inhibition.