Author

René C. L. Olsthoorn

Leiden UniversityORCID 0000-0003-0315-3005Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Antonius P. A. JansseniD· 1 shared Bjorn R. van DoodewaerdiD· 1 shared Hans van den Elst· 1 shared Indy BroekhuizeniD· 1 shared Jana S HoffmanniD· 1 shared Mariska D. Tacoma· 1 shared Marta ArtolaiD· 1 shared Paul P. GeurinkiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

Antonius P. A. JanssenORCID

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2 papers

Recent·Most cited

BiochemistryNucleic Acids ResearchPeer-reviewedAug 27, 2025

High-throughput competitive binding assay for targeting RNA with small molecules: discovery of new PreQ1 riboswitch ligands

Sophie E.L. Wintermans, Jana S Hoffmann, Victor van Kuijk…·René C. L. Olsthoorn

This paper develops a competitive binding HTS assay to identify small molecule ligands for bacterial PreQ1 riboswitches, discovering 4 hits with activity against multiple riboswitches and one showing translation inhibition.

4 citations

bacteria (other)experimental assay

𝕏 PostBluesky

Molecular BiologyGenePeer-reviewedJun 12, 2019

Relevance of the iron-responsive element (IRE) pseudotriloop structure for IRP1/2 binding and validation of IRE-like structures using the yeast three-hybrid system

Shih-Cheng Chen, René C. L. Olsthoorn

This study uses the yeast three-hybrid system to analyze the structural requirements of IREs for IRP1/2 binding and validates IRE-like structures from different genes.

19 citations

experimental assay

𝕏 PostBluesky