RNAi-based discrimination of exogenous DNA by mitotic heterochromatin in fission yeast
Hirohisa Ebina, Mattia Valentini, Haochen Yu, Lisa Baumgartner, Karl C.F. Olsen, Rajendran Rajeswaran, Sigurd J Braun, Olivier Voinnet, Yves Barral
This study identifies a mechanism in fission yeast that discriminates exogenous DNA by converting it into heterochromatin via RNAi, leading to its unequal partitioning and elimination during mitosis.
bioRxiv · Mar 27, 2026 · PreprintCell Biology