Sigurd J Braun

This study shows that the CHD remodeler Mit1 initiates heterochromatin formation and H3K9 methylation independently of Clr4, revealing a remodeler-writer feedback mechanism.

This study identifies a mechanism in fission yeast that discriminates exogenous DNA by converting it into heterochromatin via RNAi, leading to its unequal partitioning and elimination during mitosis.

This study identifies the MCUR1-CCDC90B complex as a mitochondrial scaffold regulating metabolic homeostasis, showing its role in amino acid metabolism and linking its deficiency to neurometabolic disease.

The paper identifies distinct epigenetic subdomains in subtelomeric heterochromatin of S. pombe, showing position-specific silencing and the role of structural variants in epigenetic stability.

The paper creates a comprehensive atlas of transcription factor interactions in S. pombe using experimental methods and introduces a web tool for exploring the data.

This study identifies domain-specific heterochromatin regulators in Schizosaccharomyces pombe using quantitative methods and genetic screening, revealing Dhm2's role in heterochromatin maintenance and replication fidelity.

This study shows Lem2, an inner nuclear membrane protein in S. pombe, recruits exosome co-factors to the nuclear periphery to regulate RNA degradation and coordinate transcripts during the mitosis-to-meiosis switch.

The paper identifies gene regulators that influence heterochromatin spreading in different chromatin contexts using a fission yeast deletion library and sensor system.

This study identifies FACT as a histone chaperone that promotes heterochromatin spreading by regulating histone turnover and H3K9 methylation states.

The paper shows that DNA damage triggers rDNA repeat relocation by phosphorylating the CLIP-cohibin complex, leading to SUMOylation and Cdc48/p97-mediated release from the nucleolus in yeast and human cells.

The paper investigates how PTMs on H2A variants in Arabidopsis affect cell functions and DNA damage response through motif-specific cross-talk.

The paper shows that H3K36me3 sequesters the acetyltransferase complex Mst2C to prevent heterochromatin de-repression in fission yeast.

The paper identifies a mechanism by which Set1/COMPASS prevents heterochromatin invasion at euchromatic sites through inhibition of Suv39/Clr4 and disruption of nucleosome stability.

The paper shows that subtelomeric sequences in S. pombe are hyper-recombinogenic and have unstable nucleosomes, with Ccq1 protecting them through heterochromatic repression.