The Hypothalamic-Pituitary-Adrenal Axis Orchestrates Energy Homeostasis during Cold Exposure
Mireia Llerins Perez, Xinran Gao, Laura Heimerl, Yuanyuan Wang, Katharina Schnabl, Uwe Firzlaff, Harald Luksch, Martin Klingenspor, Nina Henriette Uhlenhaut, Dehua Wang, Yongguo Li
This study identifies the dual role of the HPA axis in regulating energy homeostasis during cold exposure through ACTH-mediated thermogenesis and glucocorticoid-driven hyperphagia.
bioRxiv · Sep 18, 2025 · PreprintPhysiology