Martin Klingenspor

Endothelial deletion of ADGRF5 (GPR116) promotes fibro-inflammatory EndMT and impairs adaptive thermogenesis in brown adipose tissue

This study shows that deleting Adgrf5 in endothelial cells of brown adipose tissue impairs thermogenic capacity during prolonged cold exposure by inducing EndMT and fibro-inflammatory changes.

Single-cell metabolic imaging and digital scoring of fat tissue remodeling by label-free metabolic imaging

This study uses label-free metabolic imaging to analyze fat tissue remodeling at the single-cell level and introduces an AI tool for phenotypic assessment.

In vitro model of human subcutaneous adipocyte spheroids for studying mitochondrial dysfunction and mitochondria activating compounds

The paper develops an in vitro model of human subcutaneous adipocyte spheroids to study mitochondrial dysfunction and test mitochondria-activating compounds in obesity.

Shiny-Calorie: A context-aware application for indirect calorimetry data analysis and visualization using R

Shiny-Calorie provides a flexible, open-source tool for analyzing and visualizing indirect calorimetry data, supporting standardized integration and statistical analysis of metabolic phenotyping datasets.

The Hypothalamic-Pituitary-Adrenal Axis Orchestrates Energy Homeostasis during Cold Exposure

This study identifies the dual role of the HPA axis in regulating energy homeostasis during cold exposure through ACTH-mediated thermogenesis and glucocorticoid-driven hyperphagia.

cOmicsArt - a customizable Omics Analysis and reporting tool

cOmicsArt provides a customizable tool for omics analysis and reporting, integrating GUI-based analysis with R for reproducibility and customization.

From Planning Stage To FAIR Data: A Practical Metadatasheet For Biomedical Scientists

This paper introduces Metadatasheet, a metadata standard designed to improve data management by aligning with the data-lifecycle and enabling structured metadata recording in Microsoft Excel.

Secretin modulates appetite via brown adipose tissue - brain axis

This study investigates how secretin induces satiation by modulating brain glucose metabolism and neural activity through the BAT-brain axis in humans.