An APP-centered molecular gateway integrates innate immunity and retinoic acid signaling to drive irreversible metamorphic commitment
Ryohei Furukawa, Mizuki Taguchi, Narufumi Kameya, Keisuke Tanaka, Haruka Sato, Takehiko Itoh, Yuh Shiwa
The paper identifies a signaling cascade in sea star metamorphosis that links innate immunity and retinoic acid signaling through an APP-centered module, with implications for human neurological disorders.
bioRxiv · Jan 24, 2026 · PreprintDevelopmental Biology