Takuma Kumamoto

This paper presents a comparative MRI resource and analysis of 16 avian species, revealing mosaic brain evolution with region-specific structural and connectivity differences.

The paper identifies two distinct developmental origins of subplate neurons in mammals through comparative single-cell and spatial transcriptomics across amniotes.

This paper shows BRCA2 loss causes genomic instability through ROS-dependent metabolic collapse, highlighting the role of glutathione metabolism and PARP inhibitors in cell death.

The paper shows that interhemispheric remodeling, a precursor to corpus callosum formation, is conserved in non-mammalian amniotes and plays a role in forming similar structures in reptiles and birds.

This study identifies NOTCH2NL as a human-specific gene promoting astrocyte proliferation and gliogenesis through expansion of glial progenitor states.

The paper shows that species-specific differences in cortical excitatory neuron subtypes arise from non-uniform scaling of neurogenesis timing, regulated by Wnt signaling in rats.

The paper shows astrocytes release ATP spontaneously and non-vesicularly, affecting hundreds of synapses without requiring calcium.

This study uses spatial transcriptomics to analyze the developing mouse brain, identifying novel molecular markers and revealing heterogeneity in the claustrum.

This paper introduces a genetic switch called iOn that enables the identification of genomic integration events by triggering gene expression upon insertion, improving transgenesis in stem cells and model organisms.