Transcription of Murine Endogenous Retrovirus MERVL Is Required for Progression of Development in Early Preimplantation Embryos
Akihiko Sakashita, Tomohiro Kitano, Hirotsugu Ishizu, Youjia Guo, Harumi Masuda, Masaru Ariura, Kensaku Murano, Haruhiko Siomi
This study shows that MERVL RNA is essential for proper regulation of the host transcriptome and chromatin state during early mouse embryo development, with knockdown causing embryonic lethality.
bioRxiv · Jul 20, 2022 · PreprintDevelopmental Biology