Hirotsugu Ishizu

This study identifies REFEE as a post-transcriptional regulator of repetitive RNAs that influences zygotic genome activation in mouse embryos.

The paper identifies Obox4 as a redundant transcription factor that promotes zygotic genome activation in mouse embryos, compensating for the loss of Dux.

The paper investigates how ADMA-histones facilitate Rhino binding to dual-strand piRNA clusters in Drosophila, supporting piRNA production.

This study shows that MERVL RNA is essential for proper regulation of the host transcriptome and chromatin state during early mouse embryo development, with knockdown causing embryonic lethality.

The paper identifies Nxf2 as a key component in the Piwi-piRNA pathway, showing it forms complexes that stabilize Piwi and Panx and initiate co-transcriptional silencing of target transcripts.