SOX2-induced IL-1alpha-mediated immune suppression drives epithelial dysplasia malignant transformation
Hülya F. Taner, Wang Gong, Zackary R. Fitzsimonds, Zaiye Li, Yuesong Wu, HE Yu-min, Kohei Okuyama, Wanqing Cheng, Jung M. Kuczura, Sashider Rajesh, Andriana Manousidaki, Shuo Feng, Miki Lee, Felipe Nör, Emily Anne Lanzel, , Yu L. Lei
This study identifies a SOX2-CCL2-IL1 pathway that drives immune suppression in precancerous epithelial dysplasia, promoting malignant transformation.
bioRxiv · Dec 6, 2024 · PreprintCancer Biology