Targeting DNA-PK is a highly conserved poxvirus innate immune evasion mechanism
Marisa Oliveira, Paul T. Manna, Damaris Ribeiro Rodrigues, Long Fung Chau, Thomas Allport, Emma Wagner, Heather Brooks, Michael A. Skinner, Efstathios S. Giotis, Amanda K. Chaplin, Rodrigo Guabiraba, Clare Elizabeth Bryant, Brian J. Ferguson
This study shows that DNA-PK is a conserved DNA sensor in chickens that poxviruses evade by targeting with OPG020/OPG031 proteins, highlighting its role in innate immunity beyond mammals.
bioRxiv · Oct 6, 2024 · PreprintImmunology