Brian J. Ferguson

The paper compares dual RNA-seq data from eight Orientia tsutsugamushi strains in endothelial cells, finding no clear gene expression patterns correlating with virulence but identifying strain-specific interferon responses and conserved bacterial pathways.

This study investigates how autoimmune-protective MDA5 variants affect RNA sensing and signaling, finding they reduce interferon response and alter filament formation and ATP hydrolysis.

This study shows that DNA-PK is a conserved DNA sensor in chickens that poxviruses evade by targeting with OPG020/OPG031 proteins, highlighting its role in innate immunity beyond mammals.

This paper models the innate immune responses of chickens and ducks to HPAIV, identifying RIG-I as a key molecular difference affecting immune outcomes.