Paul D. Wes

Insight into the scaffolding function of USP18 from a high resolution cryo-EM structure of STAT2-USP18-ISG15 ternary complex

The paper determines the structure of the STAT2-USP18-ISG15 ternary complex using cryo-EM, revealing how USP18's scaffolding function suppresses IFN-I signaling by disrupting its enzymatic activity.

Discovery of conformation-sensitive anti-amyloid protofibril monoclonal antibodies using an engineered chaperone-like amyloid-binding protein

This paper describes a method to stabilize A{beta} protofibrils using an engineered chaperone-like protein, enabling the discovery of conformation-sensitive anti-A{beta} monoclonal antibodies that target protofibrils over monomers or plaques.