Insight into the scaffolding function of USP18 from a high resolution cryo-EM structure of STAT2-USP18-ISG15 ternary complex
Kevin W. Huynh, Rachel Plumb, David R. Healy, Veronica Jové, Erik C. Ralph, Chiachin Wilson Lee, Heather Wheeler, Kymberly K. Levine, Zhen Huang, Kimberly F. Fennell, Richard A. Corpina, Timothy K. Craig, Paul D. Wes, Paula M. Loria, Monica Schenone, , Masaya Yamaguchi
The paper determines the structure of the STAT2-USP18-ISG15 ternary complex using cryo-EM, revealing how USP18's scaffolding function suppresses IFN-I signaling by disrupting its enzymatic activity.
bioRxiv · Feb 12, 2026 · PreprintMolecular Biology