Author

Heiner Koch

German Cancer Research Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioinformatics· 1 Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:protein folding & dynamics· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jürgen CoxiD· 2 shared Kyle L. Fort· 2 shared Markus LubeckiD· 2 shared Scarlet Koch· 2 shared Albert J. R. HeckiD· 1 shared Alexander Gross· 1 shared Alexander Harder· 1 shared Amy L. KessleriD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBioinformatics

Jürgen CoxORCID

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Author profile →

5 papers

Recent·Most cited

Increased EThcD efficiency on the hybrid Orbitrap Excedion Pro Mass Analyzer extends the depth in identification and sequence coverage of HLA class I immunopeptidomes

Amy L. Kessler, Kyle L. Fort, Hanno Christoph Resemann, Peter Krüger, Cong Wang, Heiner Koch, Jan-Peter Hauschild, Fabio Marino, Albert J. R. Heck

This study shows that using EThcD on a new mass spectrometer improves the identification and sequence coverage of HLA class I immunopeptidomes by filling gaps in fragmentation data.

Molecular & Cellular Proteomics · Aug 12, 2025Peer-reviewedBiochemistry

Enhancing tandem MS sensitivity and peptide identification via ion pre-accumulation in an Orbitrap mass spectrometer

Florian Harking, Ulises H. Guzmán, Julia Kraegenbring, Hamish I. Stewart, Konstantin Aizikov, Heiner Koch, Kyle L. Fort, Alexander Harder, Jesper Velgaard Olsen

This paper introduces a new scanning strategy called pre-accumulation to enhance ion utilization and sensitivity in Orbitrap mass spectrometers, improving peptide and protein identification in high-throughput proteomics.

Journal of Proteome Research · Jun 30, 2025Peer-reviewedBiochemistry

Up-regulated transcriptional regulators in mutant RAS gene signatures: a time-resolved multi-omics study in generic epithelial cell models

Katharina Kasack, Patrick Metzger, Heiner Koch, Bertram Klinger, Anastasia V. Malek, Oleg I. Tchernitsa, Alexander Gross, Wasco Wruck, Balázs Győrffy, Bernhard Küster, Christine Sers, Melanie Börries, Reinhold Schäfer

This study identifies HMGA2 as a master regulator of mutant RAS-driven gene expression by analyzing time-resolved transcriptome and proteome changes in epithelial cells.

bioRxiv · Jun 4, 2024 · PreprintCancer Biology

MaxQuant software for ion mobility enhanced shotgun proteomics

Nikita A. Prianichnikov, Heiner Koch, Scarlet Koch, Markus Lubeck, Raphael Heilig, Sven Brehmer, Román Fischer, Jürgen Cox

The paper introduces an enhanced MaxQuant software for ion mobility shotgun proteomics, improving quantification accuracy and coverage using 4D data analysis.

Molecular & Cellular Proteomics · Mar 10, 2020Peer-reviewedBioinformatics

Online parallel accumulation - serial fragmentation (PASEF) with a novel trapped ion mobility mass spectrometer

Florian Meier, Andreas‐David Brunner, Scarlet Koch, Heiner Koch, Markus Lubeck, Michael Krause, Niels Goedecke, Jens Decker, Thomas Kosinski, Melvin A. Park, Nicolai Bache, Ole B. Hørning, Jürgen Cox, Oliver Raether, Matthias Mann

The paper introduces the timsTOF Pro instrument with online PASEF, achieving high sensitivity and reproducibility in proteomics.

Molecular & Cellular Proteomics · Nov 5, 2018Peer-reviewedSystems Biology