Author

Reinhold Schäfer

Deutsches Konsortium für Translationale KrebsforschungORCID 0000-0001-7952-2124Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Bertram KlingeriD· 3 shared Anja SieberiD· 2 shared David SteinbrechtiD· 2 shared Florian UhlitziD· 2 shared Ghanem El KassemiD· 2 shared Jasmine Hillmer· 2 shared Jennifer von Schlichting· 2 shared Michael BoettcheriD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersSystems Biology

Bertram KlingerORCID

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3 papers

Recent·Most cited

Perturb-seq identifies TCF7 as a central nexus linking MAPK- and Wnt-driven gene expression

Ghanem El Kassem, Anja Sieber, Bertram Klinger, Florian Uhlitz, David Steinbrecht, Mirjam van Bentum, Jasmine Hillmer, Jennifer von Schlichting, Reinhold Schäfer, Nils Blüthgen, Michael Boettcher

The paper uses Perturb-seq to identify TCF7 as a key integrator of MAPK and Wnt signaling pathways through a feedback loop with EGR1.

bioRxiv · Dec 16, 2025 · PreprintSystems Biology

Up-regulated transcriptional regulators in mutant RAS gene signatures: a time-resolved multi-omics study in generic epithelial cell models

Katharina Kasack, Patrick Metzger, Heiner Koch, Bertram Klinger, Anastasia V. Malek, Oleg I. Tchernitsa, Alexander Gross, Wasco Wruck, Balázs Győrffy, Bernhard Küster, Christine Sers, Melanie Börries, Reinhold Schäfer

This study identifies HMGA2 as a master regulator of mutant RAS-driven gene expression by analyzing time-resolved transcriptome and proteome changes in epithelial cells.

bioRxiv · Jun 4, 2024 · PreprintCancer Biology

Targeted Perturb-seq Reveals EGR1 and FOS as Key Regulators of the Transcriptional RAF-MAPK Response

Ghanem El Kassem, Anja Sieber, Bertram Klinger, Florian Uhlitz, David Steinbrecht, Mirjam van Bentum, Jasmine Hillmer, Jennifer von Schlichting, Reinhold Schäfer, Nils Blüthgen, Michael Boettcher

This study uses targeted Perturb-seq to identify EGR1 and FOS as key regulators of the transcriptional RAF-MAPK response by constructing a directional interaction network.

bioRxiv · Jan 13, 2024 · PreprintSystems Biology