Raphael Heilig

Adaptor protein 2 sigma subunit (AP2S1) variants associated with neurodevelopmental disorders

The paper identifies AP2S1 variants linked to neurodevelopmental disorders by showing they impair clathrin-mediated endocytosis and disrupt protein interactions.

Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase

This paper determines the crystal structure of KLHL3 in complex with a WNK3 peptide, revealing structural features and phosphorylation-dependent regulation of WNK3 binding.

Transcriptional changes are regulated by metabolic pathway dynamics but decoupled from protein levels

The paper shows that transcriptional changes during biological rhythms do not directly affect protein levels, which remain constant due to slow turnover rates and post-translational regulation.

MaxQuant software for ion mobility enhanced shotgun proteomics

The paper introduces an enhanced MaxQuant software for ion mobility shotgun proteomics, improving quantification accuracy and coverage using 4D data analysis.