Sry-modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: Four Core Genotypes and more
Arthur P. Arnold, Xuqi Chen, Michael N. Grzybowski, Janelle Ryan, Dale Robert Sengelaub, Tara Mohanroy, Vada Andree Furlan, Helen R. Schmidtke, Jeremy W. Prokop, Monika Tutaj, Julia L. Ciosek, Ted Kalbfleisch, Liza O’Donnell, William Grisham, Shanie Landen, , Aron M. Geurts
The paper develops rat models with modified sex chromosomes to study sex differences in physiology and disease by comparing XX vs. XY and varying X/Y chromosome numbers.
Biology of Sex Differences · Feb 21, 2026Peer-reviewedGenetics