The paper develops rat models with modified sex chromosomes to study sex differences in physiology and disease by comparing XX vs. XY and varying X/Y chromosome numbers.

Biology of Sex Differences · Feb 21, 2026Peer-reviewedGenetics

Four-Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage

Jasper Panten, Stefania Prete, James Cleland, Lauren M. Saunders, Job van Riet, Anja Schneider, Paul Adrian Ginno, Nina Schneider, Marie-Luise Koch, Xuqi Chen, Moritz Gerstung, Oliver Stegle, Arthur P. Arnold, James M. A. Turner, Édith Heard, Duncan T. Odom

The paper identifies an X-Y translocation in Four-Core Genotypes mice that increases Tlr7 expression and affects genetic interpretation.

Nature Communications · Oct 11, 2024Peer-reviewedGenetics

Relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in tissue gene regulation

Montgomery Blencowe, Xuqi Chen, Yutian Zhao, Yuichiro Itoh, Caden N. McQuillen, Yanjie Han, Benjamin L. Shou, Rebecca McClusky, Karen Reue, Arthur P. Arnold, Xia Yang

The paper investigates the relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in gene regulation in liver and adipose tissues using the FCG mouse model.

Genome Research · Apr 8, 2022Peer-reviewedSystems Biology

Cardiac Sex Differences are Established Prior to Gonad Formation

Wei Shi, Xinlei Sheng, Kerry M. Dorr, Josiah E. Hutton, Haley A. Davies, Tia D. Andrade, Todd M. Greco, Yutaka Hashimoto, Joel D. Federspiel, Zachary L. Robbe, Xuqi Chen, Arthur P. Arnold, Ileana M. Cristea, Frank L. Conlon

The paper identifies sex-specific transcriptomes and proteomes in cardiac tissue, showing that sex differences are established before gonad formation through post-transcriptional mechanisms and hormonal/sex chromosomal factors.

bioRxiv · Sep 29, 2020 · PreprintDevelopmental Biology