The paper develops rat models with modified sex chromosomes to study sex differences in physiology and disease by comparing XX vs. XY and varying X/Y chromosome numbers.

Biology of Sex Differences · Feb 21, 2026Peer-reviewedGenetics

Molecular Landscape of Modality-Specific Exercise Adaptation in Human Skeletal Muscle through Large-Scale Multi-OMICs Integration

Macsue Jacques, Shanie Landen, Adam Philip Sharples, ANDREW P. GARNHAM, Ralf B. Schittenhelm, Joel Stele, Aino Heikkinen, Elina Sillanpää, Miina Ollikainen, James R. Broatch, Navabeh Zarekookandeh, Ola Hanson, Ola Ekström, Olof Asplund, Séverine Lamon, , Nir Eynon

This study integrates multi-OMIC data from 12 cohorts to identify exercise-specific molecular signatures and gene regulatory patterns in human skeletal muscle.

bioRxiv · Jul 14, 2024 · PreprintMolecular Biology

ACTN3 genotype influences androgen response in skeletal muscle

Kelly N. Roeszler, Michael See, Lyra R. Meehan, Giscard Humberto Oliveira Lima, Alexander Kolliari-Turner, Sarah E. Alexander, Shanie Landen, Harrison D. Wood, Chrystal F. Tiong, Wei‐Yi Chen, Tomris Mustafa, Peter J. Houweling, Nir Eynon, Séverine Lamon, Yannis Paul Pitsiladis, , Jane T. Seto

This study shows that ACTN3 genotype affects androgen response in skeletal muscle by altering AR expression and pathways related to muscle homeostasis.

bioRxiv · Apr 25, 2024 · PreprintGenetics

Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle

Sarah Amandine Caroline Voisin, Kirsten Seale, Macsue Jacques, Shanie Landen, Nicholas R. Harvey, Larisa Margaret Haupt, Lyn Robyn Griffiths, Kevin J. Ashton, Vernon G. Coffey, Jamie‐Lee M. Thompson, Thomas M. Doering, Maléne E. Lindholm, Colum P. Walsh, Gareth W. Davison, Rachelle E Irwin, , Nir Eynon

This study shows exercise training reduces epigenetic and transcriptomic aging in human skeletal muscle, while muscle disuse accelerates transcriptomic aging.

Aging Cell · May 2, 2023Peer-reviewedMolecular Biology

DNA methylation and proteomics integration uncover dose-dependent group and individual responses to exercise in human skeletal muscle

Macsue Jacques, Shanie Landen, Javier Alvarez‐Romero, Danielle Hiam, Ralf B. Schittenhelm, Iresha Hanchapola, Anup D. Shah, Nir Eynon

This study integrates DNA methylation and proteomics data from human skeletal muscle to identify group and individual responses to high-intensity interval training.

bioRxiv · Jul 11, 2022 · PreprintMolecular Biology

Skeletal muscle methylome and transcriptome integration reveals profound sex differences related to muscle function and substrate metabolism

Shanie Landen, Macsue Jacques, Danielle Hiam, Javier Alvarez‐Romero, Nicholas R. Harvey, Larisa Margaret Haupt, Lyn Robyn Griffiths, Kevin J. Ashton, Séverine Lamon, Sarah Amandine Caroline Voisin, Nir Eynon

The paper integrates skeletal muscle methylome and transcriptome data across three cohorts to identify sex differences in DNA methylation and gene expression, revealing functional links between epigenetic and transcriptional sex biases.

Clinical Epigenetics · Dec 1, 2021Peer-reviewedGenomics

Meta-analysis of genome-wide DNA methylation and integrative OMICs in human skeletal muscle.

Sarah Amandine Caroline Voisin, Macsue Jacques, Shanie Landen, Nicholas R. Harvey, Larisa Margaret Haupt, Lyn Robyn Griffiths, Sofiya Gancheva, Meriem Ouni, Markus Jähnert, Kevin J. Ashton, VG Coffey, Jamie‐Lee M. Thompson, Thomas M. Doering, Anne Gabory, Claudine Junien, , Nir Eynon

The paper identifies age-related DNA methylation changes in human skeletal muscle through a meta-analysis and integrates these with transcriptomic and proteomic data, revealing enriched age-related gene expression patterns.

bioRxiv · Sep 28, 2020 · PreprintGenetics