Author

Helena M. Hinterding

Max Planck Institute for Biology of Ageing

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Erik B. van den AkkeriD· 2 shared Joris DeeleniD· 2 shared Maarouf BaghdadiiD· 2 shared Mara NeuerburgiD· 2 shared P. Eline SlagboomiD· 2 shared Almut Nebel· 1 shared Andreas BeyeriD· 1 shared Antonios PapadakisiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetics

Erik B. van den AkkerORCID

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2 papers

Recent·Most cited

Rare genetic variants in the IIS/mTOR signalling pathway identified in exceptionally long-lived individuals show shared in vitro effects associated with lifespan across species

Mara Neuerburg, Larissa Smulders, Erik B. van den Akker, Daniel Kolbe, Filippo Artoni, Isabell Brusius, Helena M. Hinterding, Laura Beltrame, Ramona Pahl, H. Eka D. Suchiman, Antonios Papadakis, Andreas Beyer, Marian Beekman, Almut Nebel, P. Eline Slagboom, , Joris Deelen

This study identifies rare genetic variants in the IIS/mTOR pathway in long-lived humans and shows they have shared functional effects on lifespan-related traits in mice.

bioRxiv · May 28, 2026 · PreprintGenetics

Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants

Helena M. Hinterding, Maarouf Baghdadi, Thies Gehrmann, Pasquale C. Putter, Mara Neuerburg, Nico Lakenberg, Erik B. van den Akker, P. Eline Slagboom, Joris Deelen, Linda Partridge

The paper identifies two rare variants in the MAPK/ERK pathway from long-lived families and shows they affect signaling and metabolism differently in mouse embryonic stem cells.

bioRxiv · Jun 1, 2023 · PreprintGenetics