Promoter mutagenesis and a massively parallel reporter screen of the MAPT locus identifies cis-regulatory elements and genetic variation effects
Rebecca M. Hauser, Henry L. Limbo, J. Nicholas Brazell, Belle A. Moyers, Shelby N. Lauzon, Erin A. Barinaga, S. Quinn Johnston, Brianne B. Rogers, Jared W. Taylor, J. Nicholas Cochran
The paper identifies cis-regulatory elements and genetic variation effects in the MAPT locus using MPRA and CRISPRi in neuronal and HEK293FT cells.
bioRxiv · Mar 25, 2026 · PreprintGenetics