Understanding monocyte-driven neuroinflammation in Alzheimers disease using human brain organoid microphysiological systems
Chunhui Tian, Zheng Ao, Jonas Cerneckis, Hongwei Cai, Lei Chen, Henyao Niu, Kazuo Takayama, Jungsu Kim, Yanhong Shi, Mingxia Gu, Takahisa Kanekiyo, Feng Guo
This study uses human brain organoid microphysiological systems to show that AD patient monocytes cause increased inflammation and reduced Aβ clearance in organoids compared to controls.
bioRxiv · Feb 16, 2025 · PreprintBioengineering