Hongwei Cai

Engineering human myelin microphysiological systems for testing patient treatment response in multiple sclerosis

This paper develops a human myelin microphysiological system to test treatment responses in multiple sclerosis patients, showing differential demyelination and immune responses between patient groups.

Transdermal diagnosis and therapy using an integrated acoustofluidic patch

This paper develops an acoustofluidic patch for transdermal biosensing and drug delivery, demonstrating its ability to detect and reverse acute allergic reactions in mice.

Brain organoid computing for robotic decision-making

This paper introduces Brainobot, a biohybrid robotic system using brain organoid reservoir computing to enable real-world decision-making tasks like object grasping and laser chasing with high efficiency and low energy consumption.

Information processing-like phenotype of human brain organoids

This study quantifies information-processing-like properties of human cortical organoids using a functional phenotyping framework, linking network function to disease-related mutations and pharmacological perturbations.

Extracellular vesicles-based point-of-care testing for the diagnosis and monitoring of Alzheimer's disease

This paper presents an OECT-based sensor for rapid, sensitive detection of extracellular vesicles in Alzheimer's disease, showing improved sensitivity and reduced detection time.

Vascular network-inspired diffusible scaffolds for engineering functional neural organoids

This paper introduces VID scaffolds to enhance diffusion in neural organoids, improving their function and drug response compared to conventional organoids.

Understanding monocyte-driven neuroinflammation in Alzheimers disease using human brain organoid microphysiological systems

This study uses human brain organoid microphysiological systems to show that AD patient monocytes cause increased inflammation and reduced Aβ clearance in organoids compared to controls.