Endothelial expression of human APP leads to cerebral amyloid angiopathy in mice
Yuriko Tachida, Saori Miura, Rie Imamaki, Naomi Ogasawara, Hiroyuki Takuwa, Naruhiko Sahara, Akihiro Shindo, Yukio Matsuba, Takashi Saito, Naoyuki Taniguchi, Yasushi Kawaguchi, Hidekazu Tomimoto, Takaomi C. Saido, Shinobu Kitazume
This study shows that expressing human APP in endothelial cells of mice leads to cerebral amyloid angiopathy, highlighting the role of both neuronal and endothelial APP in vascular Aβ deposition.
bioRxiv · Jul 22, 2020 · PreprintNeuroscience