Naruhiko Sahara

The paper describes the development of triple MAPT mutation knock-in mice that exhibit early tau pathology and behavioral abnormalities, useful for studying frontotemporal dementia and related tauopathies.

This study develops a PET ligand to visualize α-synuclein pathologies in Parkinson's and DLB patients, showing increased signals in affected brain regions.

The paper shows that MRS-measured Glutamate and GABA levels in awake mice correlate with excitatory and inhibitory neural activities during stimulation and in a Dravet syndrome model.

This study tracks tau fibrillogenesis and microglial phagocytosis of neurons in a living tauopathy model, showing that microglia engulf tangle-bearing neurons and that TSPO ligands can reduce this process.

This study shows that expressing human APP in endothelial cells of mice leads to cerebral amyloid angiopathy, highlighting the role of both neuronal and endothelial APP in vascular Aβ deposition.

This paper develops a PET-based method using ecDHFR and TMP analogs to image neuronal networks in mammalian brains, enabling visualization of neuronal activity and protein dynamics.