Author

Yasushi Kawaguchi

The University of Tokyo Pandemic Preparedness, Infection and Advanced Research CenterORCID 0000-0001-8232-6925Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Akihisa KatoiD· 2 shared Yuhei MaruzuruiD· 2 shared Akihiro ShindoiD· 1 shared Akinori KanaiiD· 1 shared Hidekazu Tomimoto· 1 shared Hiroyuki TakuwaiD· 1 shared Kosuke Takeshima· 1 shared Masahide SekiiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMicrobiology

Akihisa KatoORCID

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3 papers

Recent·Most cited

Calmodulin controls the tempo of HSV-1 gene-expression cascade to reshape infection heterogeneity

Yuhei Maruzuru, Yuta Kuze, Masahide Seki, Akinori Kanai, Shaocong Liu, Akihisa Kato, Yutaka Suzuki, Yasushi Kawaguchi

This study identifies calmodulin as a host factor that accelerates HSV-1 gene-expression tempo, increasing virus-producing cells and protecting mice from lethal infection.

bioRxiv · Jul 2, 2026 · PreprintMicrobiology

Identification of Viral Activators of the HSV-2 UL13 Protein Kinase

Naoto Koyanagi, Kosuke Takeshima, Saori Shio, Yuhei Maruzuru, Akihisa Kato, Yasushi Kawaguchi

This paper identifies HSV-2 UL55 and Us10 as viral activators of the UL13 protein kinase, showing UL55 is a principal activator and Us10 is an auxiliary activator for kinase activity and viral replication.

Journal of Virology · Sep 30, 2025Peer-reviewedMicrobiology

Endothelial expression of human APP leads to cerebral amyloid angiopathy in mice

Yuriko Tachida, Saori Miura, Rie Imamaki, Naomi Ogasawara, Hiroyuki Takuwa, Naruhiko Sahara, Akihiro Shindo, Yukio Matsuba, Takashi Saito, Naoyuki Taniguchi, Yasushi Kawaguchi, Hidekazu Tomimoto, Takaomi C. Saido, Shinobu Kitazume

This study shows that expressing human APP in endothelial cells of mice leads to cerebral amyloid angiopathy, highlighting the role of both neuronal and endothelial APP in vascular Aβ deposition.

bioRxiv · Jul 22, 2020 · PreprintNeuroscience