Hiroyuki Takuwa

This study uses quantum dot imaging temperature sensors to measure brain temperature in mice, revealing vascular cooling's role in protecting against heat stress in pathological conditions.

This study develops a PET ligand to visualize α-synuclein pathologies in Parkinson's and DLB patients, showing increased signals in affected brain regions.

The paper introduces a method to visualize neurotransmission at synapses using split protein sensors, demonstrating functionality in cultured cells, worms, and mouse brains.

The paper shows that MRS-measured Glutamate and GABA levels in awake mice correlate with excitatory and inhibitory neural activities during stimulation and in a Dravet syndrome model.

This study tracks tau fibrillogenesis and microglial phagocytosis of neurons in a living tauopathy model, showing that microglia engulf tangle-bearing neurons and that TSPO ligands can reduce this process.

This study shows that expressing human APP in endothelial cells of mice leads to cerebral amyloid angiopathy, highlighting the role of both neuronal and endothelial APP in vascular Aβ deposition.

This paper introduces deschloroclozapine (DCZ), a potent and selective DREADD agonist that rapidly modulates neuronal activity and behavior in mice and monkeys.

This paper develops a PET-based method using ecDHFR and TMP analogs to image neuronal networks in mammalian brains, enabling visualization of neuronal activity and protein dynamics.