Author

Yukio Matsuba

RIKEN Center for Brain Science

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4

Frequent Co-Authors

Takaomi C. SaidoiD· 4 shared Takashi SaitoiD· 4 shared Hiroki SasaguriiD· 2 shared Misaki Sekiguchi· 2 shared Naomasa Kakiya· 2 shared Naomi Mihira· 2 shared Naoto WatamuraiD· 2 shared Nobuhisa IwataiD· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Takaomi C. SaidoORCID

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4 papers

Recent·Most cited

CXCL10 drives female-specific tau pathology progression and defines sex-dependent vulnerability in tauopathy model mice

Ryohei Uenishi, Rinna Kawata, Tatsuya Manabe, Yukio Matsuba, Naomi Mihira, Toru Takeo, Takaomi C. Saido, Masanori Hijioka, Takashi Saito

This study identifies CXCL10 as a driver of female-specific tau pathology progression in tauopathy model mice, revealing a sex-dependent mechanism independent of T cell or glial activation.

Journal of Neuroinflammation · Aug 5, 2026Peer-reviewedNeuroscience

Metabolic resistance of Abeta3pE-42, epitope of the anti-Alzheimer therapeutic antibody, donanemab.

Nobuhisa Iwata, Satoshi Tsubuki, Misaki Sekiguchi, Kaori Watanabe-Iwata, Yukio Matsuba, Naoko Kamano, Ryo Fujioka, Risa Takamura, Naoto Watamura, Naomasa Kakiya, Naomi Mihira, Takahiro Morito, Keiro Shirotani, David M. A. Mann, Andrew Robinson, , Takaomi C. Saido

This paper investigates the metabolic stability and deposition of A{beta}3pE-42, a target of the Alzheimer's antibody donanemab, showing it is more stable than other A{beta}X-42 species and accumulates with age.

Life Science Alliance · Sep 30, 2024Peer-reviewedNeuroscience

Neprilysin-sensitive amyloidogenic Aβ versus IDE-sensitive soluble Aβ: a probable mechanistic cause for sporadic Alzheimer's disease

Hiroki Sasaguri, Risa Takamura, Naoto Watamura, Naomasa Kakiya, Toshio Ohshima, Ryo Fujioka, Naomi Yamazaki, Misaki Sekiguchi, Kaori Iwata, Yukio Matsuba, Shoko Hashimoto, Satoshi Tsubuki, Takashi Saito, Nobuhisa Iwata, Takaomi C. Saido

This study compares the roles of NEP and IDE in Aβ metabolism using double knockout mice, finding NEP primarily degrades insoluble Aβ and its deficiency contributes to AD pathology.

bioRxiv · Aug 22, 2021 · PreprintNeuroscience

Endothelial expression of human APP leads to cerebral amyloid angiopathy in mice

Yuriko Tachida, Saori Miura, Rie Imamaki, Naomi Ogasawara, Hiroyuki Takuwa, Naruhiko Sahara, Akihiro Shindo, Yukio Matsuba, Takashi Saito, Naoyuki Taniguchi, Yasushi Kawaguchi, Hidekazu Tomimoto, Takaomi C. Saido, Shinobu Kitazume

This study shows that expressing human APP in endothelial cells of mice leads to cerebral amyloid angiopathy, highlighting the role of both neuronal and endothelial APP in vascular Aβ deposition.

bioRxiv · Jul 22, 2020 · PreprintNeuroscience