Cancer BiologybioRxivPreprint
Chemical inhibition of RPA gap protection sensitizes BRCA1-deficient cancers to PARP inhibition
Pamela S. VanderVere-Carozza, Matthew R. Jordan, Joy Garrett…·John J. Turchi
This study shows that inhibiting RPA gap protection enhances PARP inhibitor efficacy in BRCA1-deficient cancers by increasing genomic instability and reducing tumor growth.