Author

Priyanka Bhatt

Cystic Fibrosis FoundationORCID 0000-0002-4531-6952Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Kevin J. CooteiD· 2 shared Martin MenseiD· 2 shared Alicia SanoycaiD· 1 shared Andrey SivachenkoiD· 1 shared Beate IllekiD· 1 shared Brigitte N. GompertsiD· 1 shared C. Macadino· 1 shared Calvin U. Cotton· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBioengineering

Kevin J. CooteORCID

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3 papers

Recent·Most cited

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site-Specific Integration of CFTR and Mutation-Agnostic Disease Rescue

Ruth A. Foley, Paul George Ayoub, Vrishti Sinha, Colin J. Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin J. Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven John Jonas

This paper develops lipid nanoparticles to deliver CRISPR/Cas9 for site-specific CFTR gene integration in CF airway cells, achieving 3-3.5% gene editing and 80% Cl- current restoration.

Advanced Functional Materials · Jan 4, 2026Peer-reviewedBioengineering

Upregulation of a nonsense mediated decay (NMD) insensitive CFTR mRNA isoform has therapeutic potential for the treatment of 3 Prime CFTR PTC variants

Norm Allaire, M. Armstrong, Jae Seok Yoon, Priyanka Bhatt, Jan Harrington, Yi Cheng, Hillary C. Valley, C. Macadino, Hermann J. Bihler, Andrey Sivachenko, Martin Mense, Calvin U. Cotton

The paper shows that upregulating an NMD-insensitive CFTR mRNA isoform with ASOs and ETI can restore partial Cl- transport function in cells with 3' PTC mutations.

bioRxiv · Jul 1, 2024 · PreprintGenomics

Anticodon Engineered Transfer RNAs (ACE-tRNAs) are a Platform Technology for Suppressing Nonsense Mutations

Wooree Ko, Joseph J. Porter, Sacha Spelier, Tyler A. Couch, Isabelle S. van der Windt, Priyanka Bhatt, Kevin J. Coote, Martin Mense, Jeffrey Matthijn Beekman, John D. Lueck

The paper demonstrates that ACE-tRNAs can suppress nonsense mutations in CF by rescuing CFTR transcript abundance and channel function in multiple models.

bioRxiv · Jun 6, 2024 · PreprintMolecular Biology