ASCL1 primes medullary thymic epithelial cell programs required for central tolerance
Nobuko Akiyama, Kenta Horie, Kano Namiki, Jen-Chien Chang, Maki Miyauchi, Takahisa Miyao, Nanako Uchida, Naho Hagiwara, Masaki Yoshida, Mizuki Morota, Tsukasa Kouno, Miki Kojima, Jonathan Moody, Yoshinari Ando, Hirotake Ichise, , Taishin Akiyama
The paper identifies ASCL1 as a key regulator of mTEC function and central tolerance by analyzing single-cell RNA sequencing data from thymoma patients and mouse models.
bioRxiv · Aug 6, 2025 · PreprintImmunology