Hyperexcitable but seizure-free: hippocampal network dysfunction in a Wolfram syndrome model
Saumel Ahmadi, Juan Gallardo Pinera, Sophie Dokholyan, Andrew D. Sauerbeck, Hong Nhung Phan, Brianna Carman, Avishek Debnath, Samuel Brunwasser, Gabriel Skinner, Nicholas R. Rensing, Michael Wong, Cory Cearlock, Susan E. Maloney, Terrance T. Kummer, Srikanth Singamaneni, , Fumihiko Urano
This study investigates hippocampal network dysfunction in a Wolfram syndrome mouse model, finding hyperexcitable neurons without seizures or increased network bursting.
bioRxiv · Oct 2, 2026 · PreprintNeuroscience