Nicholas R. Rensing

Hyperexcitable but seizure-free: hippocampal network dysfunction in a Wolfram syndrome model

This study investigates hippocampal network dysfunction in a Wolfram syndrome mouse model, finding hyperexcitable neurons without seizures or increased network bursting.

Persistence of vestibular function in the absence of glutamatergic transmission from hair cells

This study shows that vestibular function remains normal in Vglut3-/- mice despite severe reduction in glutamatergic synaptic transmission, suggesting non-quantal transmission compensates for the loss.

Chronic oral cannabidiol delays or prevents seizures in a mouse model of CLN2 disease

This study shows that chronic cannabidiol treatment delays or prevents seizures in a mouse model of CLN2 disease without affecting traditional neuroimmune markers.

GABAergic interneurons contribute to the fatal seizure phenotype of CLN2 disease mice

This study investigates the role of GABAergic interneurons in seizure progression and mortality in CLN2 disease mice, finding that interneuron dysfunction contributes to epileptic seizures and death.

A role for δ subunit-containing GABA-A receptors on parvalbumin positive neurons in maintaining electrocortical signatures of sleep states

The paper investigates the role of δ subunit-containing GABA-A receptors on parvalbumin positive neurons in shaping electrocortical activity during sleep states, finding altered EEG patterns in their absence.

Periodic and aperiodic changes to cortical EEG in response to pharmacological manipulation

The paper examines how pharmacological manipulations affect the aperiodic exponent of EEG power spectra in mice, finding it is not a reliable marker of excitation/inhibition balance.

Spatial and Amplitude Dynamics of Neurostimulation: Insights from the Acute Intrahippocampal Kainate Seizure Mouse Model

This study identifies optimal spatial and amplitude parameters for neurostimulation in a mouse seizure model, showing that higher amplitude stimulation at specific hippocampal regions significantly reduces epileptiform activity.

Effects of chronic cannabidiol in a mouse model of naturally occurring neuroinflammation, neurodegeneration, and spontaneous seizures

This study examines the effects of chronic CBD in a mouse model of neuroinflammation, neurodegeneration, and seizures, finding reduced astrocytosis and microgliosis but no impact on seizures or neuron survival.

Cortical interneuron loss and seizure generation as novel clinically relevant disease phenotypes in Cln2R207X mice

This study identifies novel disease phenotypes in Cln2R207X mice, including cortical interneuron loss and seizure generation, providing insights into CLN2 disease pathogenesis.