Michael Wong

This study investigates hippocampal network dysfunction in a Wolfram syndrome mouse model, finding hyperexcitable neurons without seizures or increased network bursting.

This study shows that vestibular function remains normal in Vglut3-/- mice despite severe reduction in glutamatergic synaptic transmission, suggesting non-quantal transmission compensates for the loss.

This study shows that chronic cannabidiol treatment delays or prevents seizures in a mouse model of CLN2 disease without affecting traditional neuroimmune markers.

This study investigates the role of GABAergic interneurons in seizure progression and mortality in CLN2 disease mice, finding that interneuron dysfunction contributes to epileptic seizures and death.

The paper investigates the role of δ subunit-containing GABA-A receptors on parvalbumin positive neurons in shaping electrocortical activity during sleep states, finding altered EEG patterns in their absence.

The paper examines how pharmacological manipulations affect the aperiodic exponent of EEG power spectra in mice, finding it is not a reliable marker of excitation/inhibition balance.

This study identifies optimal spatial and amplitude parameters for neurostimulation in a mouse seizure model, showing that higher amplitude stimulation at specific hippocampal regions significantly reduces epileptiform activity.

This study examines the effects of chronic CBD in a mouse model of neuroinflammation, neurodegeneration, and seizures, finding reduced astrocytosis and microgliosis but no impact on seizures or neuron survival.

This study identifies novel disease phenotypes in Cln2R207X mice, including cortical interneuron loss and seizure generation, providing insights into CLN2 disease pathogenesis.