Towards the Development of Isoenergetic Peptide Nucleic Acid Based Probes Targeting Double-Stranded RNAs Through Enhancing Sequence-Specific Stacking Interactions
Rongguang Lu, Kun Xi, Ruiyu Lin, Manchugondanahalli S. Krishna, Yanyu Chen, Xuan Zhan, Honghao Zeng, Xue Li, Shijian Fan, Hanting Zhou, Wenzheng Wu, Yun Lian, Yuze Dai, Lizhe Zhu, Guobao Li, Gang Chen
This paper investigates how modifying PNA with s2U adjacent to Q residues enhances binding affinity and functional activity toward dsRNAs, demonstrating broader applicability in targeting structured RNA structures.
bioRxiv · Jun 28, 2025 · PreprintBiochemistry