Author

Shijian Fan

Chinese University of Hong Kong, Shenzhen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Synthetic Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3

Frequent Co-Authors

Gang CheniD· 3 shared Hanting Zhou· 3 shared Rongguang LuiD· 3 shared Yanyu CheniD· 3 shared Yun Lian· 3 shared Guobao LiiD· 2 shared Kun XiiD· 2 shared Lizhe ZhuiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

Gang ChenORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A programmable mRNA platform for miRNA detection via miRNA-mRNA2 triplex-mediated ribosomal frameshifting

Yanyu Chen, Wanqi Zhao, Huizhen Chen, Hanting Zhou, Shijian Fan, Liping Xing, Yun Lian, Hongyu Duan, Yuze Dai, Zheng Zhao, Rongguang Lu, Chenzhong Li, Cheng Jiang, Ho Yin Edwin Chan, Gang Chen

This paper develops a programmable mRNA platform that detects specific miRNAs by converting their presence into a quantifiable protein output through miRNA-triggered ribosomal frameshifting.

ACS Synthetic Biology · Jul 17, 2026Peer-reviewedSynthetic Biology

Towards the Development of Isoenergetic Peptide Nucleic Acid Based Probes Targeting Double-Stranded RNAs Through Enhancing Sequence-Specific Stacking Interactions

Rongguang Lu, Kun Xi, Ruiyu Lin, Manchugondanahalli S. Krishna, Yanyu Chen, Xuan Zhan, Honghao Zeng, Xue Li, Shijian Fan, Hanting Zhou, Wenzheng Wu, Yun Lian, Yuze Dai, Lizhe Zhu, Guobao Li, Gang Chen

This paper investigates how modifying PNA with s2U adjacent to Q residues enhances binding affinity and functional activity toward dsRNAs, demonstrating broader applicability in targeting structured RNA structures.

bioRxiv · Jun 28, 2025 · PreprintBiochemistry

Recognition of RNA secondary structures with a programmable peptide nucleic acid-based platform

Rongguang Lu, Liping Deng, Yun Lian, Xin Ke, Lixia Yang, Kun Xi, Alan Ann Lerk Ong, Yanyu Chen, Hanting Zhou, Zhenyu Meng, Ruiyu Lin, Shijian Fan, Yining Liu, Desiree‐Faye Kaixin Toh, Xuan Zhan, , Gang Chen

This paper introduces daPNAs, a programmable platform combining dbPNAs and asPNAs to target RNA junctions, demonstrating their use in inhibiting Dicer and regulating ribosomal frameshifting.

Cell Reports Physical Science · Aug 12, 2024Peer-reviewedBiochemistry