Species-specific regulation of porcine STING stability and antiviral signaling via its K61 mediated K48 ubiquitination and proteasome degradation
Nengwen Xia, Yajing Chang, Chenglin Chi, Ziyan Sun, Anjing Liu, Wangli Zheng, Jun Jiao, Hongjian Han, Jingyu He, Jiajia Zhang, Nanhua Chen, Sen Jiang, Wanglong Zheng, Jianzhong Zhu
This study identifies K61-mediated K48 ubiquitination and proteasome degradation of porcine STING as a species-specific mechanism regulating antiviral signaling.
bioRxiv · Mar 29, 2026 · PreprintImmunology