Oncometabolite fumarate impairs ATR-CHK1 signaling by succinating RPA1 in Fumarate Hydratase-deficient renal cell carcinoma cells
Nian Liu, Changxian Shen, Tingting Zhou, Yu Zhou, Hang Yuan, Hongjie Bi, Yingying Wang, Xinyu Pei, Rui Jun Su, Vijay Trisal, Li Zheng, Yihui H. Shi, Binghui Shen
This study shows fumarate impairs ATR-CHK1 signaling by succinating RPA1, leading to defective DNA repair and cell cycle control in FH-dRCC.
Cancer & Metabolism · Apr 28, 2026Peer-reviewedCancer Biology