Cancer BiologyCancer & MetabolismPeer-reviewed
Oncometabolite fumarate impairs ATR-CHK1 signaling by succinating RPA1 in Fumarate Hydratase-deficient renal cell carcinoma cells
Nian Liu, Changxian Shen, Tingting Zhou…·Binghui Shen
This study shows fumarate impairs ATR-CHK1 signaling by succinating RPA1, leading to defective DNA repair and cell cycle control in FH-dRCC.
DOI 10.1186/s40170-026-00435-4