The cGAS-STING pathway is an in vivo modifier of genomic instability syndromes
Marva Bergman, Uri Goshtchevsky, Tehila Atlan, Gwendoline Astre, Ryan Halabi, Hosniyah El, Eitan Moses, Aaron J.J. Lemus, Bérénice Anath Benayoun, Yehuda Tzfati, Ido Ben‐Ami, Itamar Harel
This study models DDR syndromes in killifish and shows that cGAS-STING pathway activation contributes to disease phenotypes, with cGAS mutation partially rescuing defects.
bioRxiv · Oct 16, 2024 · PreprintGenetics